Design and Evaluation of Cellulose-Alginate Nanoparticles as an Effective Delivery System for Controlled Release of Doxorubicin

The main purpose of the present study was to synthesize cellulose nanoparticles with gelation of alginate core to provide excellent solubility in aqueous solution and to and characterize the resulting nanomedicine after loading with Doxorubicin, an anticancer agent. Cellulose exhibits the property of biodegradation and compatibility with body tissues and in combination with doxorubicin provides toxicity to cancer tissues. These nanoparticles were characterized under scanning electron microscopy, Fourier transform infrared spectroscopy to find topology, crystal structure and chemical purity of nanoparticles. The release of doxorubicin from cellulose-alginate nanoparticles was studied by in vitro method using a dialysis membrane in the presence of phosphate buffer. Under suitable conditions, the cellulose-alginate nanoparticles obtained were in size ranging between 10 and 100 nm. The in vitro drug release revealed the controlled release of drug from the polymer in a sustained manner. The percentage release of drug released from the dialysis bag was found to be 78% at the end of 72 hours.